M-CSF/CSF1 Protéine

N° du produit ABIN2829986

Protéine Recombinant M-CSF/CSF1 exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour M-CSF/CSF1 Protéine (ABIN2829986)

Antigène: M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: Escherichia coli (E. coli)

Application: Functional Studies (Func)

Pureté: >95 % as determined by SDS-PAGE and HPLC.

Détail du produit

Séquence: KEVSEHCSHM IGNGHLKVLQ QLIDSQMETS CQIAFEFVDQ EQLDDPVCYL KKAFFLVQDI IDETMRFKDN TPNANATERL QELSNNLNSC FTKDYEEQNK ACVRTFHETP LQLLEKIKNF FNETKNLLEK DWNIFTKNCN NSFAKCSSRD VVTKPDCNCL YPKATPSSDP ASASPHQPPA PSMAPLAGLA WDDSQRTEGS SLLPSELPLR IEDPGSAKQR PPRSTCQTLE

Attributs du produit: Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine M-NFS-60 cells is less than 2 ng/mL, corresponding to a specific activity of ＞ 5.0 x 105 IU/mg.

Stérilité: 0.2 μm filtered

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 20 mM Tris, 500 mM NaCl, pH 7.4

Stock: -20 °C

Détail du antigène

Antigène: M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Autre désignation: Csf1

Sujet: Relevance: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
Synonyms: CSF-1,

Poids moléculaire: 52.0 kDa

UniProt: P07141

Pathways: Signalisation RTK